Periconceptional growth hormone treatment alters early uterine environment
نویسندگان
چکیده
منابع مشابه
Periconceptional growth hormone treatment alters early uterine environment
We have shown that an injection of sustained release growth hormone (GH), given just prior to breeding, results in lambs that are 25% heavier at birth, with an altered body composition as evidenced by an increased abdominal girth, but no difference in crown rump length. The mechanisms by which these differences occur from a single periconceptional injection are not yet known. Therefore, the obj...
متن کاملPericonceptional growth hormone treatment alters fetal growth and development in lambs.
Research in the area of fetal programming has focused on intrauterine growth restriction. Few studies have attempted to examine programming mechanisms that ultimately lead to lambs with a greater potential for postnatal growth. We previously demonstrated that treatment of ewes with GH at the time of breeding led to an increase in birth weight. Therefore, the objective of this study was to deter...
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Sixteen prepubertal children who were insufficient for growth hormone were treated with growth hormone releasing hormone (GHRH) 1-40 and GHRH 1-29 for a mean time of nine months (range 6-12 months) with each peptide. Eleven children received GHRH 1-40 in four subcutaneous nocturnal pulses (dose 4-8 micrograms/kg/day) and eight (three of whom were also treated with GHRH 1-40) received GHRH 1-29 ...
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Until 1985 growth hormone (GH) was obtained from pituitary extracts, and was available in limited amounts only to treat severe growth hormone deficiency (GHD). With the availability of unlimited quantities of GH obtained from recombinant DNA technology, researchers started to explore new modalities to treat GHD children, as well as to treat a number of other non-GHD conditions. Although with so...
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3T3-F442A adipocytes incubated in the presence of growth hormone (GH) showed a transient stimulation of the incorporation of [14C]glucose into cellular lipids, or production of 14CO2 in the first 4 hr. By 48 hr, a significant suppression of glucose metabolism was evident, and persisted for 7 days. Both effects resulted from direct in vitro addition of GH to 3T3 adipocytes. This system therefore...
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ژورنال
عنوان ژورنال: Open Journal of Animal Sciences
سال: 2013
ISSN: 2161-7597,2161-7627
DOI: 10.4236/ojas.2013.32018